Negative regulation by host of viral transcription

Across TCGA patient cohorts, RNA activity of the Negative regulation by host of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0513, HMGA2, and ABCB9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral transcription activity versus KIAA0513 in GBM (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIAA0513 →	-0.790	-0.192	<.001	.001	3	5
LUAD	HMGA2 →	+1.294	+0.221	<.001	<.001	3	4
PDAC	ABCB9 →	+0.303	+0.260	<.001	<.001	3	4
HNSC	E2F7 →	+0.783	+0.242	<.001	<.001	3	4
LUAD	HMGA2-AS1 →	+1.054	+0.217	<.001	<.001	3	4
LSCC	POLR2H →	+0.536	+0.181	.004	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043922 vs KIAA0513 — GBM

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