Dedifferentiation

Across TCGA patient cohorts, RNA activity of the Dedifferentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA4, SVIL, and VCL_Y822, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dedifferentiation activity versus SERPINA4 in OV (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINA4 →	+0.778	+0.102	<.001	<.001	3	9
GBM	SVIL →	+0.553	+0.134	<.001	<.001	3	9
OV	VCL_Y822 →	+0.977	+0.087	.001	.001	3	9
GBM	C8G →	+0.583	+0.089	<.001	.002	3	9
UCEC	ILK →	+0.443	+0.086	<.001	.005	3	9
OV	ITGA5 →	+0.527	+0.084	.003	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043696 vs SERPINA4 — OV

Explore this scatter interactively →