Dedifferentiation

Across TCGA patient cohorts, RNA activity of the Dedifferentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF12, SH3BGRL, and TBC1D5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dedifferentiation activity versus TNFSF12 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFSF12 →	-0.497	-0.279	.001	.001	3	5
PDAC	SH3BGRL →	-0.358	-0.156	<.001	<.001	3	4
GBM	TBC1D5 →	-0.306	-0.190	<.001	.002	3	3
GBM	USP30 →	-0.265	-0.200	.002	.005	3	3
GBM	EIF4E3 →	-0.358	-0.219	.006	.001	3	3
GBM	TANGO2 →	-0.209	-0.152	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043696 vs TNFSF12 — LSCC

Explore this scatter interactively →