Reverse cholesterol transport

Across TCGA patient cohorts, RNA activity of the Reverse cholesterol transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMSAP2_S599, VAT1, and TALDO1_S237, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reverse cholesterol transport activity versus CAMSAP2_S599 in CCRCC (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CAMSAP2_S599 →	-0.361	-0.083	.004	.008	3	6
GBM	VAT1 →	+0.347	+0.068	<.001	.002	3	6
LSCC	TALDO1_S237 →	+0.420	+0.051	<.001	<.001	3	5
LSCC	CES1 →	+1.201	+0.058	<.001	<.001	3	5
LSCC	GSTM2 →	+0.739	+0.056	<.001	<.001	3	5
UCEC	SSH1 →	-0.251	-0.047	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043691 vs CAMSAP2_S599 — CCRCC

Explore this scatter interactively →