Reverse cholesterol transport

Across TCGA patient cohorts, RNA activity of the Reverse cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, RASGRP4, and COLEC12, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reverse cholesterol transport activity versus MMP19 in GBM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP19 →	+1.300	+0.132	<.001	<.001	3	8
BRCA	RASGRP4 →	+0.551	+0.166	<.001	<.001	3	8
BRCA	COLEC12 →	+0.961	+0.131	.002	.004	3	8
OV	SRPX →	+1.008	+0.155	<.001	<.001	3	7
OV	MEDAG →	+1.877	+0.219	<.001	<.001	3	7
OV	SERPINE1 →	+1.354	+0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043691 vs MMP19 — GBM

Explore this scatter interactively →