Reverse cholesterol transport

Across TCGA cell cohorts, RNA activity of the Reverse cholesterol transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT7, PYHIN1, and FKBP1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT7 grouped by Reverse cholesterol transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUDT7 →	-0.114	-0.163	.004	.003	3	4
OVARY	PYHIN1 →	+0.242	+0.212	.008	.003	3	4
BLOOD_Lymphoma	FKBP1A →	+0.354	+0.120	.001	.003	3	4
LIVER	FASN →	+0.333	+0.435	<.001	<.001	3	4
LUNG_SCLC	PRR19 →	-0.244	-0.148	<.001	<.001	3	4
SOFT_TISSUE	RHO →	-0.156	-0.264	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT7 by Reverse cholesterol transport activity — LARGE_INTESTINE

Explore this box plot interactively →