Reverse cholesterol transport

Across TCGA cell cohorts, RNA activity of the Reverse cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOE, MED9, and ERCC6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reverse cholesterol transport activity versus APOE in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	APOE →	+4.372	+0.970	<.001	.008	3	4
OVARY	MED9 →	+0.605	+0.807	.001	.002	3	4
OESOPHAGUS	ERCC6 →	-0.863	-0.841	<.001	.001	3	4
URINARY_TRACT	TLDC2 →	+0.590	+1.491	.001	<.001	3	3
URINARY_TRACT	ARL10 →	+1.945	+1.488	.002	<.001	3	3
URINARY_TRACT	LIN9 →	+0.384	+1.194	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043691 vs APOE — SKIN

Explore this scatter interactively →