Mitochondrial fragmentation involved in apoptotic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial fragmentation involved in apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO7, SMC4, and PCM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fragmentation involved in apoptotic process activity versus XPO7 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XPO7 →	+0.296	+0.057	.005	.001	3	5
LUAD	SMC4 →	+0.396	+0.042	<.001	<.001	3	5
COAD	PCM1 →	+0.303	+0.054	<.001	<.001	3	5
COAD	CSE1L →	+0.232	+0.043	.003	.001	3	5
BRCA	LYRM1 →	-0.540	-0.046	<.001	<.001	3	5
LUAD	SELENBP1 →	-0.576	-0.045	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043653 vs XPO7 — OV

Explore this scatter interactively →