Engulfment of apoptotic cell

Across TCGA cell cohorts, RNA activity of the Engulfment of apoptotic cell pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTC1, UBE3D, and PDSS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTC1 grouped by Engulfment of apoptotic cell-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CTC1 →	-0.997	-1.352	<.001	<.001	3	5
LUNG_SCLC	UBE3D →	-0.762	-1.167	.002	.002	3	4
LARGE_INTESTINE	PDSS2 →	-0.699	-1.120	<.001	<.001	3	4
LARGE_INTESTINE	CNTROB →	-0.572	-1.188	.003	<.001	3	4
LARGE_INTESTINE	SLC2A4 →	-0.820	-1.197	<.001	.001	3	4
LARGE_INTESTINE	EEF1AKMT4 →	-0.470	-0.807	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTC1 by Engulfment of apoptotic cell activity — KIDNEY

Explore this box plot interactively →