Dicarboxylic acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, BEND3, and ITGA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC2 grouped by Dicarboxylic acid biosynthetic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAC2 →	-4.340	-1.224	<.001	<.001	3	6
LUNG_SCLC	BEND3 →	+0.806	+1.233	.009	<.001	3	4
LUNG_NSCLC_LUSC	ITGA3 →	-2.620	-1.194	.007	<.001	3	4
BLOOD_Lymphoma	MT2A →	-5.312	-1.656	.008	.003	3	4
LUNG_NSCLC_LUSC	ALDH1A1 →	+4.561	+1.330	.001	<.001	3	4
BLOOD_Lymphoma	PDE8B →	+0.670	+1.444	<.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC2 by Dicarboxylic acid biosynthetic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →