Dicarboxylic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, TBC1D2B, and F12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid catabolic process activity versus ZYX in UCEC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZYX →	-0.491	-0.053	.002	<.001	3	7
HNSC	TBC1D2B →	-0.163	-0.040	<.001	<.001	3	7
UCEC	F12 →	-0.457	-0.055	.002	<.001	3	6
OV	FER →	-0.391	-0.051	<.001	<.001	3	6
HNSC	MICAL1 →	-0.336	-0.051	<.001	.003	3	6
COAD	MRPL44 →	+0.372	+0.029	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043649 vs ZYX — UCEC

Explore this scatter interactively →