Dicarboxylic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC59, PIMREGP2, and CKAP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid catabolic process activity versus LRRC59 in COAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LRRC59 →	-0.405	-0.198	<.001	<.001	3	4
CCRCC	PIMREGP2 →	+0.085	+0.153	.002	.003	3	4
GBM	CKAP4 →	-0.360	-0.179	.001	.003	3	4
PDAC	KLF15 →	+1.091	+0.176	<.001	.003	3	4
PDAC	BHLHA15 →	+1.195	+0.179	<.001	<.001	3	4
GBM	FCER2 →	+0.481	+0.220	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043649 vs LRRC59 — COAD

Explore this scatter interactively →