Dicarboxylic acid catabolic process

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD109, MEST, and PCCB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid catabolic process activity versus CD109 in OESOPHAGUS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD109 →	-2.092	-0.224	.008	.001	3	6
URINARY_TRACT	MEST →	-5.260	-0.347	.002	.003	3	4
LIVER	PCCB →	+1.040	+0.326	<.001	<.001	3	4
LIVER	TLR6 →	-1.411	-0.326	<.001	<.001	3	4
LIVER	CHST15 →	-1.615	-0.298	.008	<.001	3	4
LUNG_SCLC	SCML2 →	+1.450	+0.333	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043649 vs CD109 — OESOPHAGUS

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