Dicarboxylic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAP1, PPIF, and RRM2_S20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid metabolic process activity versus TRAP1 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRAP1 →	+0.443	+0.018	.004	.008	3	7
LUAD	PPIF →	+0.434	+0.030	<.001	.003	3	7
LUAD	RRM2_S20 →	+0.729	+0.026	.002	<.001	3	6
OV	TOMM34 →	+0.530	+0.026	<.001	.003	3	6
UCEC	DNAJC2 →	+0.268	+0.049	<.001	<.001	3	6
HNSC	HSPA14 →	+0.281	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043648 vs TRAP1 — OV

Explore this scatter interactively →