Dicarboxylic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSTL3, NPEPL1, and TUBB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FSTL3 grouped by Dicarboxylic acid metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FSTL3 →	-1.436	-0.821	<.001	.004	3	4
LUNG_SCLC	NPEPL1 →	-1.185	-0.910	.001	.003	2	5
STOMACH	TUBB6 →	-3.787	-1.075	.002	.005	3	4
STOMACH	SLC37A2 →	-2.858	-1.461	.007	<.001	3	4
BREAST	PANK2 →	-0.786	-0.975	<.001	<.001	3	4
BREAST	GPNMB →	-2.490	-1.031	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FSTL3 by Dicarboxylic acid metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →