Keratinocyte proliferation

Across TCGA patient cohorts, RNA activity of the Keratinocyte proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLASRP_S547, STIP1, and CPQ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte proliferation activity versus CLASRP_S547 in OV (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLASRP_S547 →	-0.396	-0.034	.005	<.001	3	7
BRCA	STIP1 →	-0.280	-0.041	.001	<.001	3	6
PDAC	CPQ →	+0.380	+0.040	<.001	<.001	3	6
PDAC	CYGB →	+0.527	+0.046	<.001	<.001	3	6
LUAD	ITSN1_S978 →	+0.711	+0.055	.008	.005	3	6
BRCA	SYNPO →	+0.517	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043616 vs CLASRP_S547 — OV

Explore this scatter interactively →