Keratinocyte proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Keratinocyte proliferation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 59 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Keratinocyte proliferation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and UCS, show the opposite pattern, with higher activity associated with better survival.

UCEC, ESCA, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.276	0.683	.003	42	view →
ESCA	DFS	Median	III,IV	0.564	0.320	.002	36	view →
LGG	DFS	Tertile	All	0.644	0.808	<.001	32	view →
UCS	DFS	Tertile	IV	0.814	0.250	.024	24	view →
CESC	DFS	Quartile	All	0.852	0.663	.009	24	view →
BLCA	DFS	Median	III,IV	0.660	0.497	.004	19	view →
PAAD	OS	Quartile	All	0.380	0.702	.003	15	view →
MESO	DFS	Quartile	II,III,IV	0.780	0.250	.006	9	view →
SARC	DFS	Quartile	All	0.319	0.578	.011	6	view →
LIHC	OS	Tertile	III,IV	0.839	0.452	.010	6	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	6	view →
DLBC	DFS	Median	III,IV	0.383	0.984	.043	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0043616–UCEC (DFS)

Open the UCEC breakdown →