Keratinocyte proliferation

Across TCGA cell cohorts, RNA activity of the Keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGAP3, PCSK1N, and LRRC39, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGAP3 grouped by Keratinocyte proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AGAP3 →	-0.618	-0.682	.002	.005	3	5
PANCREAS	PCSK1N →	-1.654	-0.945	.002	.004	3	4
KIDNEY	LRRC39 →	-0.378	-1.304	.003	<.001	3	4
KIDNEY	STRBP →	-0.908	-1.180	.002	.008	3	4
CNS	FUZ →	-1.774	-1.121	<.001	<.001	3	3
CNS	PRRG1 →	+0.607	+0.793	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGAP3 by Keratinocyte proliferation activity — BREAST

Explore this box plot interactively →