Keratinocyte proliferation

Across TCGA cell cohorts, RNA activity of the Keratinocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLLT11, PPP3R2, and TTR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLLT11 grouped by Keratinocyte proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MLLT11 →	-0.260	-1.733	.005	<.001	2	7
LUNG_SCLC	PPP3R2 →	+0.264	+1.842	.001	<.001	3	4
CNS	TTR →	-0.144	-1.027	.007	.003	3	4
CNS	LRRC8C →	-0.450	-1.641	.005	.005	3	4
BLOOD_Myeloma	GNA11 →	-0.237	-1.578	.006	<.001	3	4
URINARY_TRACT	KLF15 →	-0.393	-0.362	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLLT11 by Keratinocyte proliferation activity — SOFT_TISSUE

Explore this box plot interactively →