Keratinocyte proliferation

Across TCGA cell cohorts, RNA activity of the Keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIAM2, FER, and LPIN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte proliferation activity versus TIAM2 in LARGE_INTESTINE (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIAM2 →	+1.083	+1.898	.001	<.001	3	3
LARGE_INTESTINE	FER →	+1.926	+1.760	<.001	<.001	3	3
LUNG_NSCLC_LUAD	LPIN2 →	+1.214	+1.220	.009	.005	3	2
LUNG_NSCLC_LUAD	DPYSL3 →	+3.444	+1.271	.001	.002	3	2
LUNG_NSCLC_LUAD	ARHGEF26 →	+2.031	+1.246	.007	.003	3	2
CNS	ANKEF1 →	-1.420	-1.890	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043616 vs TIAM2 — LARGE_INTESTINE

Explore this scatter interactively →