Tongue morphogenesis

Across TCGA patient cohorts, RNA activity of the Tongue morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TSPAN6, SEC24D, and DOCK2_S1592, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue morphogenesis activity versus TSPAN6 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSPAN6 →	+0.860	+0.096	<.001	.001	3	6
CCRCC	SEC24D →	-0.243	-0.078	.001	<.001	3	5
LSCC	DOCK2_S1592 →	-0.736	-0.079	<.001	.001	3	5
OV	IGF1R →	+0.395	+0.035	.004	.004	2	6
LSCC	ZEB2 →	-0.357	-0.099	<.001	<.001	3	5
CCRCC	PACS1_T504 →	+0.617	+0.067	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043587 vs TSPAN6 — UCEC

Explore this scatter interactively →