Tongue morphogenesis

Across TCGA patient cohorts, RNA activity of the Tongue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIL, LMOD3, and WARS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue morphogenesis activity versus STIL in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STIL →	+0.538	+0.142	<.001	<.001	3	5
HNSC	LMOD3 →	-1.362	-0.142	<.001	<.001	3	5
LSCC	WARS1 →	+0.407	+0.157	.004	<.001	3	4
LSCC	EMSLR →	+0.592	+0.178	<.001	.003	3	4
HNSC	SLC25A5 →	+0.503	+0.107	<.001	.001	3	4
OV	EMD →	+0.348	+0.608	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043587 vs STIL — HNSC

Explore this scatter interactively →