Tongue morphogenesis

Across TCGA cell cohorts, RNA activity of the Tongue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1, RPH3AL, and TSPAN10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPD1 grouped by Tongue morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPD1 →	-1.390	-1.211	.003	<.001	3	4
BREAST	RPH3AL →	-1.120	-0.832	.007	.002	3	3
BREAST	TSPAN10 →	+0.636	+0.930	.006	.001	3	3
BREAST	KIF9 →	-0.653	-1.146	.009	<.001	3	3
BLOOD_Leukemia	BBS2 →	+0.613	+0.818	.007	.005	3	3
SKIN	CREB3 →	+0.695	+0.745	.007	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPD1 by Tongue morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →