Tongue morphogenesis

Across TCGA cell cohorts, RNA activity of the Tongue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARFGAP3, NDUFB11, and MIER1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue morphogenesis activity versus ARFGAP3 in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARFGAP3 →	-1.011	-0.964	<.001	.002	3	3
CNS	NDUFB11 →	+0.437	+1.347	.002	<.001	3	3
CNS	MIER1 →	-0.668	-1.715	.007	.008	3	3
CNS	PKN2 →	-0.486	-1.338	.003	.004	3	3
KIDNEY	LIPA →	-1.724	-2.159	.002	.003	3	3
KIDNEY	KAZALD1 →	-1.880	-2.254	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043587 vs ARFGAP3 — BREAST

Explore this scatter interactively →