Tongue development

Across TCGA patient cohorts, RNA activity of the Tongue development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUB1, ITGB5, and PPA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue development activity versus SUB1 in GBM (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SUB1 →	-0.330	-0.051	.008	<.001	3	6
LUAD	ITGB5 →	+0.298	+0.052	.007	<.001	3	6
PDAC	PPA1 →	-0.288	-0.089	<.001	<.001	3	6
PDAC	PRRX1 →	+0.480	+0.065	<.001	<.001	3	6
HNSC	RBM47 →	-0.315	-0.064	<.001	<.001	3	6
OV	JCAD_S885 →	+0.478	+0.040	.009	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043586 vs SUB1 — GBM

Explore this scatter interactively →