Tongue development

Across TCGA cell cohorts, RNA activity of the Tongue development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAB2, SLC9A6, and ZC3H12B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECAB2 grouped by Tongue development-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NECAB2 →	-0.110	-1.624	.002	<.001	3	4
OVARY	SLC9A6 →	+0.864	+1.348	<.001	<.001	3	3
BONE	ZC3H12B →	-1.038	-1.404	.001	.002	3	3
BONE	MATN3 →	+1.962	+1.440	.004	.006	2	4
URINARY_TRACT	MGAT5B →	+2.392	+1.436	.001	.009	3	3
PANCREAS	VCP →	+0.746	+0.964	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECAB2 by Tongue development activity — BLOOD_Lymphoma

Explore this box plot interactively →