Tongue development

Across TCGA cell cohorts, RNA activity of the Tongue development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WARS2, WDR26, and DBR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WARS2 grouped by Tongue development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WARS2 →	-0.324	-1.660	.002	.001	3	4
LIVER	WDR26 →	+0.223	+1.685	.008	.003	3	3
PANCREAS	DBR1 →	-0.414	-1.744	.004	.004	3	3
BREAST	ANAPC1 →	-0.596	-1.669	.001	.001	2	4
OVARY	CCDC12 →	+0.242	+1.462	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PARGP1 →	-0.270	-2.017	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WARS2 by Tongue development activity — LARGE_INTESTINE

Explore this box plot interactively →