Nose development

Across TCGA patient cohorts, RNA activity of the Nose development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB5, ABCC6, and AGPAT5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nose development activity versus NDUFB5 in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFB5 →	-0.253	-0.307	.001	.003	3	3
UCEC	ABCC6 →	-0.690	-0.395	<.001	.005	3	3
HNSC	AGPAT5 →	+0.423	+0.294	.004	<.001	3	3
LUAD	RAB38 →	-1.019	-0.400	<.001	.001	3	3
LSCC	OSGIN1 →	-1.235	-0.341	.001	<.001	3	3
LUAD	MBOAT2 →	-0.395	-0.193	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043584 vs NDUFB5 — UCEC

Explore this scatter interactively →