Nose development

Across TCGA cell cohorts, RNA activity of the Nose development pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTR2C, LEMD2, and RAB29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HTR2C grouped by Nose development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HTR2C →	+0.092	+0.117	.009	.004	3	4
STOMACH	LEMD2 →	+0.319	+0.161	.007	.002	3	4
OESOPHAGUS	RAB29 →	+0.165	+0.094	<.001	.001	3	3
OESOPHAGUS	MMAA →	+0.264	+0.101	.002	<.001	3	3
OESOPHAGUS	TVP23A →	+0.267	+0.075	.003	.001	3	3
OESOPHAGUS	DCTN1 →	-0.337	-0.076	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HTR2C by Nose development activity — STOMACH

Explore this box plot interactively →