Ear development

Across TCGA patient cohorts, RNA activity of the Ear development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBS2, DEF6, and FKBP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ear development activity versus BBS2 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BBS2 →	+0.493	+0.048	<.001	<.001	3	7
LSCC	DEF6 →	-0.415	-0.031	<.001	<.001	3	7
LSCC	FKBP9 →	+0.554	+0.031	<.001	<.001	3	7
BRCA	LTBP3 →	+0.491	+0.023	<.001	<.001	3	7
HNSC	MYO1G →	-0.420	-0.032	<.001	<.001	3	7
GBM	ASAP3 →	+0.366	+0.019	.008	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043583 vs BBS2 — UCEC

Explore this scatter interactively →