Ear development

Across TCGA patient cohorts, RNA activity of the Ear development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF516, RPP40, and TSKS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ear development activity versus ZNF516 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF516 →	+0.754	+0.473	<.001	<.001	3	3
BRCA	RPP40 →	-0.589	-0.575	<.001	.001	3	3
BRCA	TSKS →	-0.218	-0.513	.008	.007	3	3
BRCA	TAS2R3 →	+0.357	+0.469	.001	.006	2	4
BRCA	MAPK8IP3 →	+0.735	+0.496	<.001	.009	3	3
BRCA	PLEKHG4B →	-1.026	-0.642	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043583 vs ZNF516 — BRCA

Explore this scatter interactively →