Negative regulation of insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, RCN3, and ASAP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of insulin-like growth factor receptor signaling pathway activity versus VCAN in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCAN →	+0.856	+0.096	<.001	<.001	3	6
LSCC	RCN3 →	+0.517	+0.073	<.001	<.001	3	5
OV	ASAP3 →	+0.431	+0.111	.001	.001	3	5
OV	THY1 →	+0.504	+0.099	<.001	<.001	3	5
LUAD	CILP →	+1.132	+0.106	<.001	<.001	3	5
BRCA	CILP2 →	+0.587	+0.116	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043569 vs VCAN — OV

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