Positive regulation of insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRK, GPRASP1, and CBLL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRK grouped by Positive regulation of insulin-like growth factor receptor signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SNRK →	-0.222	-1.179	<.001	<.001	3	5
OVARY	GPRASP1 →	-0.226	-0.975	.001	<.001	3	4
LUNG_SCLC	CBLL1 →	+0.329	+1.215	<.001	.004	2	5
KIDNEY	MED12 →	+0.430	+1.176	<.001	.001	3	4
SKIN	PITPNM2 →	+0.107	+0.774	.002	.001	2	4
BONE	PXK →	-0.220	-1.528	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRK by Positive regulation of insulin-like growth factor receptor signaling pathway activity — CNS

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