Regulation of translational initiation in response to stress

Across TCGA patient cohorts, RNA activity of the Regulation of translational initiation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC1, KIF20A, and PTTG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational initiation in response to stress activity versus DEPDC1 in LUAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEPDC1 →	+0.857	+0.193	<.001	<.001	3	8
LUAD	KIF20A →	+1.081	+0.194	<.001	<.001	3	7
BRCA	PTTG1 →	+0.981	+0.202	<.001	<.001	3	7
BRCA	SHCBP1 →	+0.859	+0.266	<.001	<.001	3	7
UCEC	CPED1 →	-0.869	-0.201	.006	<.001	3	6
BRCA	NDNF →	-1.151	-0.204	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043558 vs DEPDC1 — LUAD

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