Regulation of lipid kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of lipid kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF763, ZNF547, and ZRANB2-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid kinase activity activity versus ZNF763 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF763 →	+0.413	+0.600	.003	.005	3	5
BRCA	ZNF547 →	+0.387	+0.835	<.001	<.001	3	4
BRCA	ZRANB2-AS1 →	+0.245	+0.591	.003	<.001	3	4
PDAC	LILRA2 →	+0.412	+0.886	<.001	<.001	3	4
LSCC	FAM111B →	-0.806	-0.891	.008	.006	3	4
HNSC	HMGB1P44 →	+0.731	+0.564	.009	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043550 vs ZNF763 — BRCA

Explore this scatter interactively →