Positive regulation of GTPase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of GTPase activity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCRC2, CAV2, and EDN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of GTPase activity activity versus UQCRC2 in SKIN (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UQCRC2 →	-0.483	-0.170	.002	.005	3	6
LUNG_SCLC	CAV2 →	+2.247	+0.160	.008	.003	3	5
LARGE_INTESTINE	EDN1 →	+2.600	+0.265	<.001	<.001	3	5
SOFT_TISSUE	PATZ1 →	-0.777	-0.178	.001	.003	3	5
STOMACH	GSR →	-1.761	-0.286	.003	.008	2	6
BREAST	HERC4 →	+0.995	+0.298	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043547 vs UQCRC2 — SKIN

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