Protein acylation

Across TCGA cell cohorts, RNA activity of the Protein acylation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT10, TREX1, and SHOC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus NAT10 in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NAT10 →	+0.867	+1.116	.004	.001	3	5
LIVER	TREX1 →	-3.077	-1.571	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SHOC2 →	-0.503	-0.772	.007	.004	3	5
BLOOD_Myeloma	ATP6AP1 →	-1.062	-1.256	.003	.003	2	5
BONE	PPP1R13L →	-1.741	-1.095	.006	.008	3	4
BONE	S100A10 →	-2.661	-1.097	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs NAT10 — OESOPHAGUS

Explore this scatter interactively →