Positive regulation of blood vessel endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood vessel endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R18, DCBLD2, and IFIT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R18 grouped by Positive regulation of blood vessel endothelial cell migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R18 →	-1.216	-0.246	<.001	<.001	3	6
BREAST	DCBLD2 →	-1.702	-0.195	.006	.001	3	6
BLOOD_Myeloma	IFIT3 →	-1.216	-0.302	.007	.002	3	5
LUNG_NSCLC_LUSC	PLAUR →	-2.583	-0.235	.002	.009	2	6
BREAST	CMTM3 →	-1.495	-0.257	.006	<.001	3	5
BREAST	PTPRR →	-0.896	-0.159	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R18 by Positive regulation of blood vessel endothelial cell migration activity — BLOOD_Leukemia

Explore this box plot interactively →