Positive regulation of blood vessel endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood vessel endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB1, GUK1, and PTPN18, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood vessel endothelial cell migration activity versus HSPB1 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HSPB1 →	+3.430	+0.342	.002	.004	3	8
LUNG_NSCLC_LUSC	GUK1 →	+0.690	+0.378	.005	<.001	3	5
BLOOD_Leukemia	PTPN18 →	+1.401	+0.242	.007	.001	3	5
STOMACH	FAM156B →	+0.723	+0.314	<.001	.001	3	5
SOFT_TISSUE	ZXDA →	+0.602	+0.378	.009	.006	3	5
URINARY_TRACT	PITPNM2 →	+0.740	+0.416	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043536 vs HSPB1 — STOMACH

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