Regulation of blood vessel endothelial cell migration

Across TCGA patient cohorts, RNA activity of the Regulation of blood vessel endothelial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPIND1, BGN, and VWA1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood vessel endothelial cell migration activity versus SERPIND1 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPIND1 →	+0.868	+0.039	<.001	<.001	3	10
UCEC	BGN →	+0.775	+0.059	<.001	<.001	3	10
UCEC	VWA1 →	+0.436	+0.072	<.001	<.001	3	10
UCEC	COL15A1 →	+0.680	+0.070	<.001	<.001	3	10
UCEC	LAMA4 →	+0.654	+0.069	<.001	<.001	3	10
UCEC	NID2 →	+0.564	+0.057	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043535 vs SERPIND1 — BRCA

Explore this scatter interactively →