Blood vessel endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Blood vessel endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTTG1, PGM1, and TMCC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTTG1 grouped by Blood vessel endothelial cell migration-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PTTG1 →	-1.504	-1.433	.001	.004	3	4
LUNG_SCLC	PGM1 →	-1.020	-0.320	.006	<.001	3	4
LUNG_NSCLC_LUAD	TMCC2 →	-0.926	-0.810	.002	.005	3	4
BREAST	ELP4 →	-0.395	-0.570	.008	<.001	3	3
SOFT_TISSUE	TTC33 →	-0.718	-0.737	.002	.003	3	3
BREAST	DNAJC8 →	-0.652	-0.729	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTTG1 by Blood vessel endothelial cell migration activity — BONE

Explore this box plot interactively →