Blood vessel endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Blood vessel endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN33, HSH2D, and CAPG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel endothelial cell migration activity versus TSPAN33 in LUNG_NSCLC_LUSC (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TSPAN33 →	-3.697	-0.253	<.001	.002	3	7
LUNG_NSCLC_LUAD	HSH2D →	+1.823	+0.243	<.001	.001	3	7
LUNG_NSCLC_LUSC	CAPG →	+5.035	+0.350	<.001	.006	3	6
STOMACH	ADAM11 →	-1.810	-0.254	.001	.006	3	6
LUNG_NSCLC_LUAD	SCML2 →	-1.442	-0.281	<.001	.001	3	6
LUNG_NSCLC_LUAD	RIPK3 →	+1.537	+0.290	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043534 vs TSPAN33 — LUNG_NSCLC_LUSC

Explore this scatter interactively →