"Positive regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGA2, IGF2BP2, and PATJ_S1212, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA damage response, signal transduction by p53 class mediator" activity versus HMGA2 in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HMGA2 →	+1.278	+0.049	<.001	.001	3	5
LSCC	IGF2BP2 →	+0.720	+0.050	<.001	<.001	3	5
CCRCC	PATJ_S1212 →	-0.533	-0.053	<.001	<.001	3	5
CCRCC	ZNF385A_S160 →	+0.435	+0.040	.001	<.001	3	5
UCEC	AFDN_S1140 →	-0.490	-0.068	<.001	.005	3	5
BRCA	YARS1 →	-0.231	-0.035	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043517 vs HMGA2 — PDAC

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