"Positive regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM200B, TANGO6, and XPO5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA damage response, signal transduction by p53 class mediator" activity versus FAM200B in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM200B →	+0.836	+0.142	.001	.006	3	6
BREAST	TANGO6 →	+1.049	+0.224	<.001	.001	3	5
LUNG_SCLC	XPO5 →	+0.580	+0.237	<.001	<.001	3	5
LARGE_INTESTINE	RPN1 →	+0.477	+0.182	.005	.003	3	5
LIVER	BYSL →	+0.829	+0.344	.002	.001	1	7
BREAST	LMTK3 →	-1.055	-0.204	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043517 vs FAM200B — LARGE_INTESTINE

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