"Regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL15, POLE2, and PIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of DNA damage response, signal transduction by p53 class mediator" activity versus IL15 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL15 →	+0.348	+0.119	.001	.001	3	5
LUAD	POLE2 →	+0.608	+0.150	<.001	.004	3	4
BRCA	PIF1 →	+0.684	+0.128	<.001	<.001	3	4
LUAD	MKI67 →	+0.779	+0.159	<.001	<.001	3	4
LUAD	DBF4B →	+0.481	+0.169	<.001	.001	3	4
BRCA	PTTG1 →	+0.695	+0.127	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043516 vs IL15 — BRCA

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