"Regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN3K, TP53I11, and ETS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FN3K grouped by "Regulation of DNA damage response, signal transduction by p53 class mediator"-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FN3K →	+1.357	+0.230	.001	<.001	3	5
LIVER	TP53I11 →	+2.660	+0.284	<.001	.005	3	4
LUNG_NSCLC_LUAD	ETS1 →	-1.677	-0.199	.001	<.001	3	4
LUNG_NSCLC_LUAD	PWWP2A →	-0.473	-0.170	<.001	.003	3	4
LUNG_SCLC	BRI3BP →	+1.374	+0.274	.004	.009	2	5
OVARY	A4GALT →	-1.646	-1.215	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FN3K by "Regulation of DNA damage response, signal transduction by p53 class mediator" activity — LARGE_INTESTINE

Explore this box plot interactively →