"Regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD44, PHYHIP, and EPB41L5, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of DNA damage response, signal transduction by p53 class mediator" activity versus CD44 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD44 →	+5.726	+0.284	.005	<.001	3	12
URINARY_TRACT	PHYHIP →	+0.860	+0.470	.006	.004	3	8
LIVER	EPB41L5 →	-1.976	-0.300	<.001	<.001	3	7
BONE	FOSL1 →	+4.516	+0.284	.004	<.001	3	7
BONE	CAPRIN2 →	+1.534	+0.299	.003	<.001	3	7
BONE	SLC25A33 →	-0.980	-0.276	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043516 vs CD44 — BONE

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