Regulation of JUN kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBIL5P, VAV3, and SPA17P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of JUN kinase activity activity versus DBIL5P in CCRCC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DBIL5P →	-0.182	-0.705	.002	.001	3	4
OV	VAV3 →	+1.777	+0.285	<.001	.001	3	3
LSCC	SPA17P1 →	+0.297	+0.590	<.001	.003	3	3
OV	TMEM270 →	-0.822	-0.353	<.001	.004	3	3
BRCA	PDGFB →	-0.518	-0.463	<.001	.002	3	3
LUAD	SOGA1 →	-0.614	-0.886	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043506 vs DBIL5P — CCRCC

Explore this scatter interactively →