Regulation of JUN kinase activity

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of JUN kinase activity pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 43 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Regulation of JUN kinase activity pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and UVM, show the opposite pattern, with higher activity associated with better survival.

KIRC, READ, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.517	0.689	<.001	98	view →
READ	OS	Median	III,IV	0.832	0.310	<.001	54	view →
UVM	OS	Quartile	III,IV	1.000	0.519	.013	53	view →
BRCA	OS	Tertile	All	0.974	0.942	.006	46	view →
LUAD	DFS	Median	IV	0.308	0.668	.001	34	view →
CHOL	OS	Quartile	All	0.201	0.781	.001	33	view →
LUSC	DFS	Quartile	III,IV	0.453	0.852	.001	24	view →
UCEC	DFS	Tertile	All	0.790	0.871	.012	18	view →
ESCA	OS	Median	III,IV	0.532	0.325	.031	16	view →
SKCM	OS	Quartile	All	0.842	0.715	.003	16	view →
DLBC	DFS	Median	All	0.579	1.000	.007	14	view →
SARC	DFS	Quartile	All	0.687	0.352	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0043506–KIRC (OS)

Open the KIRC breakdown →