Regulation of JUN kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM3, DUSP5, and ERICH6B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMTM3 grouped by Regulation of JUN kinase activity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CMTM3 →	-1.716	-0.985	.002	.003	3	4
BREAST	DUSP5 →	-1.078	-0.407	<.001	.005	3	4
STOMACH	ERICH6B →	-0.488	-1.245	.003	.007	3	3
LARGE_INTESTINE	GLCCI1 →	-1.019	-0.998	.004	.004	3	3
LARGE_INTESTINE	KLHL7 →	-0.509	-1.067	.002	<.001	3	3
LARGE_INTESTINE	SPX →	-0.329	-1.348	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMTM3 by Regulation of JUN kinase activity activity — LARGE_INTESTINE

Explore this box plot interactively →